Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of intracellular signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNOT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNOT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNOT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:58,392,269–58,393,124 | 237.2 kb | Distal (>10kb) Multiome | 993 | |
| chr16:58,463,143–58,465,363 | 166.1 kb | Distal (>10kb) Multiome | 307 | |
| chr16:58,487,547–58,488,283 | 142.0 kb | Distal (>10kb) Multiome | 523 | |
| chr16:58,499,699–58,500,457 | 129.8 kb | Distal (>10kb) Multiome | 283 | |
| chr16:58,500,548–58,502,121 | 128.4 kb | Distal (>10kb) Multiome | 481 | |
| chr16:58,511,772–58,512,394 | 117.7 kb | Distal (>10kb) Multiome | 355 | |
| chr16:58,515,027–58,516,681 | 114.3 kb | Distal (>10kb) Multiome HiCAR | 1010 | |
| chr16:58,629,310–58,630,709 | 346 bp | At TSS Multiome | 1050 | |
| chr16:58,634,505–58,634,716 | 4.7 kb | Proximal (<10kb) | 230 | |
| chr16:58,684,159–58,685,101 | 54.9 kb | Distal (>10kb) Multiome | 695 | |
| chr16:58,733,415–58,734,721 | 104.4 kb | Distal (>10kb) Multiome | 1031 | |
| chr16:58,756,000–58,756,694 | 126.7 kb | Distal (>10kb) Multiome | 352 | |
| chr16:58,862,372–58,863,064 | 233.0 kb | Distal (>10kb) Multiome | 145 |
Genomic view of the CNOT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.