This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DLG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:77,711,094–77,711,911 | 215.2 kb | Distal (>10kb) Multiome | 389 | |
| chr10:77,846,603–77,847,343 | 79.8 kb | Distal (>10kb) Multiome | 348 | |
| chr10:77,877,430–77,878,558 | 48.8 kb | Distal (>10kb) Multiome | 354 | |
| chr10:77,889,322–77,889,884 | 37.2 kb | Distal (>10kb) Multiome | 368 | |
| chr10:77,925,988–77,927,324 | 135 bp | At TSS Multiome | 571 | |
| chr10:77,949,053–77,949,566 | 22.6 kb | Distal (>10kb) Multiome | 366 | |
| chr10:78,028,918–78,030,205 | 102.9 kb | Distal (>10kb) Multiome | 902 | |
| chr10:78,033,398–78,034,359 | 107.1 kb | Distal (>10kb) Multiome | 879 | |
| chr10:78,047,166–78,047,758 | 120.7 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the DLG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.