This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for IGF2BP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGF2BP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGF2BP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:185,581,887–185,582,879 | 242.7 kb | Distal (>10kb) Multiome | 125 | |
| chr3:185,585,767–185,586,789 | 238.8 kb | Distal (>10kb) Multiome | 851 | |
| chr3:185,786,185–185,786,786 | 38.6 kb | Distal (>10kb) Multiome | 166 | |
| chr3:185,823,241–185,823,399 | 1.6 kb | Proximal (<10kb) | 320 | |
| chr3:185,823,485–185,823,948 | 1.1 kb | Proximal (<10kb) | 388 | |
| chr3:185,824,058–185,826,626 | 223 bp | At TSS Multiome | 789 | |
| chr3:185,937,142–185,938,541 | 113.0 kb | Distal (>10kb) Multiome | 1100 | |
| chr3:185,943,380–185,943,981 | 118.6 kb | Distal (>10kb) Multiome | 545 | |
| chr3:185,983,585–185,984,068 | 158.8 kb | Distal (>10kb) Multiome | 356 | |
| chr3:186,079,815–186,080,525 | 255.0 kb | Distal (>10kb) Multiome | 173 | |
| chr3:186,097,348–186,098,508 | 272.8 kb | Distal (>10kb) Multiome | 650 | |
| chr3:186,108,150–186,110,388 | 284.2 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the IGF2BP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.