The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LBR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LBR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LBR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:225,424,635–225,425,809 | 2.8 kb | Proximal (<10kb) Multiome | 399 | |
| chr1:225,427,208–225,428,777 | 80 bp | At TSS Multiome | 921 | |
| chr1:225,446,105–225,447,138 | 18.5 kb | Distal (>10kb) Multiome | 178 | |
| chr1:225,474,969–225,475,612 | 47.1 kb | Distal (>10kb) Multiome | 742 | |
| chr1:225,627,340–225,627,898 | 199.5 kb | Distal (>10kb) Multiome | 254 | |
| chr1:225,652,334–225,654,131 | 225.2 kb | Distal (>10kb) Multiome | 786 | |
| chr1:225,809,711–225,811,548 | 382.1 kb | Distal (>10kb) Multiome HiCAR | 654 | |
| chr1:225,910,978–225,911,799 | 483.4 kb | Distal (>10kb) Multiome HiCAR | 344 | |
| chr1:225,939,444–225,939,998 | 511.6 kb | Distal (>10kb) Multiome HiCAR | 62 |
Genomic view of the LBR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.