This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017]
Transcription factors with Perturb-seq knockdown data for HNRNPU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:244,651,947–244,654,106 | 211.6 kb | Distal (>10kb) Multiome | 921 | |
| chr1:244,730,143–244,731,325 | 133.8 kb | Distal (>10kb) Multiome | 295 | |
| chr1:244,815,498–244,816,101 | 48.8 kb | Distal (>10kb) Multiome | 177 | |
| chr1:244,833,808–244,836,513 | 29.2 kb | Distal (>10kb) Multiome | 1226 | |
| chr1:244,862,633–244,865,438 | 95 bp | At TSS Multiome | 1124 | |
| chr1:244,969,529–244,971,459 | 106.1 kb | Distal (>10kb) Multiome HiCAR | 1136 | |
| chr1:245,051,083–245,052,207 | 187.2 kb | Distal (>10kb) Multiome HiCAR | 353 | |
| chr1:245,093,040–245,095,301 | 229.8 kb | Distal (>10kb) Multiome | 322 | |
| chr1:245,153,093–245,157,406 | 292.1 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the HNRNPU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.