Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; midbody; and mitotic spindle. Implicated in familial restrictive cardiomyopathy 6. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIF20A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF20A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF20A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:138,032,174–138,033,856 | 146.1 kb | Distal (>10kb) Multiome | 889 | |
| chr5:138,036,018–138,036,514 | 143.0 kb | Distal (>10kb) Multiome | 359 | |
| chr5:138,095,141–138,095,876 | 83.7 kb | Distal (>10kb) Multiome | 194 | |
| chr5:138,178,003–138,178,116 | 1.0 kb | Proximal (<10kb) | 125 | |
| chr5:138,178,349–138,179,428 | 273 bp | At TSS Multiome | 789 | |
| chr5:138,212,899–138,214,126 | 34.3 kb | Distal (>10kb) Multiome | 747 | |
| chr5:138,241,684–138,242,313 | 62.9 kb | Distal (>10kb) Multiome | 397 | |
| chr5:138,247,699–138,248,212 | 68.8 kb | Distal (>10kb) Multiome | 13 | |
| chr5:138,274,126–138,274,706 | 95.2 kb | Distal (>10kb) Multiome | 161 | |
| chr5:138,331,426–138,332,354 | 152.8 kb | Distal (>10kb) Multiome | 686 | |
| chr5:138,337,358–138,339,397 | 159.0 kb | Distal (>10kb) Multiome | 1134 | |
| chr5:138,352,125–138,353,730 | 173.5 kb | Distal (>10kb) Multiome | 868 | |
| chr5:138,438,317–138,439,353 | 259.8 kb | Distal (>10kb) Multiome | 421 | |
| chr5:138,449,690–138,450,452 | 271.0 kb | Distal (>10kb) Multiome | 486 | |
| chr5:138,463,424–138,467,199 | 286.0 kb | Distal (>10kb) Multiome | 1117 |
Genomic view of the KIF20A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.