UBE2S
ubiquitin conjugating enzyme E2 S | E2-EPF

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

Member of: DE-11 DE-11.5
Biological processes 31 terms
anaphase-promoting complex (GO:0005680)anaphase-promoting complex binding (GO:0010997)anaphase-promoting complex-dependent catabolic process (GO:0031145)anaphase-promoting complex-dependent catabolic process (GO:0031145)cytosol (GO:0005829)exit from mitosis (GO:0010458)exit from mitosis (GO:0010458)exit from mitosis (GO:0010458)free ubiquitin chain polymerization (GO:0010994)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of ubiquitin protein ligase activity (GO:1904668)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein K11-linked ubiquitination (GO:0070979)protein K11-linked ubiquitination (GO:0070979)protein K27-linked ubiquitination (GO:0044314)protein K29-linked ubiquitination (GO:0035519)protein K6-linked ubiquitination (GO:0085020)protein K63-linked ubiquitination (GO:0070534)protein binding (GO:0005515)protein modification by small protein conjugation (GO:0032446)protein modification process (GO:0036211)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-like protein transferase activity (GO:0019787)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
UBE2S — as a Regulated Gene

TFs regulating UBE2S 0 TFs

Transcription factors with Perturb-seq knockdown data for UBE2S. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2S upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to UBE2S

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2S, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:55,117,134–55,119,109 290.1 kb Distal (>10kb) Multiome 881
chr19:55,146,210–55,148,117 260.8 kb Distal (>10kb) Multiome 528
chr19:55,156,193–55,157,266 251.2 kb Distal (>10kb) Multiome 317
chr19:55,160,567–55,161,360 247.0 kb Distal (>10kb) Multiome 554
chr19:55,165,952–55,167,256 241.1 kb Distal (>10kb) Multiome 719
chr19:55,173,717–55,174,287 233.7 kb Distal (>10kb) Multiome 330
chr19:55,178,876–55,179,477 228.7 kb Distal (>10kb) Multiome 479
chr19:55,216,490–55,217,227 190.9 kb Distal (>10kb) Multiome 1077
chr19:55,257,751–55,259,635 148.6 kb Distal (>10kb) Multiome 1054
chr19:55,279,599–55,280,933 127.5 kb Distal (>10kb) Multiome HiCAR 805
chr19:55,283,835–55,284,716 123.7 kb Distal (>10kb) Multiome HiCAR 242
chr19:55,301,640–55,302,240 105.8 kb Distal (>10kb) Multiome 448
chr19:55,338,676–55,340,358 68.2 kb Distal (>10kb) Multiome 882
chr19:55,340,675–55,341,535 66.4 kb Distal (>10kb) Multiome 368
chr19:55,353,720–55,354,487 53.7 kb Distal (>10kb) Multiome 297
chr19:55,369,099–55,370,447 37.8 kb Distal (>10kb) Multiome 383
chr19:55,383,539–55,384,553 23.9 kb Distal (>10kb) Multiome 374
chr19:55,384,697–55,386,560 22.1 kb Distal (>10kb) Multiome 903
chr19:55,406,950–55,408,675 269 bp At TSS Multiome 965
chr19:55,452,738–55,453,308 45.3 kb Distal (>10kb) Multiome 339
chr19:55,460,784–55,462,230 54.0 kb Distal (>10kb) Multiome 947
chr19:55,476,048–55,477,307 68.9 kb Distal (>10kb) Multiome 1007
chr19:55,484,846–55,485,682 77.4 kb Distal (>10kb) Multiome 594
chr19:55,503,638–55,504,310 96.2 kb Distal (>10kb) Multiome 710
chr19:55,516,768–55,517,459 109.3 kb Distal (>10kb) Multiome 583
chr19:55,536,923–55,537,366 129.4 kb Distal (>10kb) Multiome 180
chr19:55,549,822–55,550,343 142.3 kb Distal (>10kb) Multiome 396
chr19:55,580,080–55,581,090 173.0 kb Distal (>10kb) Multiome 718
chr19:55,585,644–55,586,314 178.1 kb Distal (>10kb) Multiome 370
chr19:55,586,698–55,587,594 179.5 kb Distal (>10kb) Multiome 463
chr19:55,598,551–55,600,991 192.6 kb Distal (>10kb) Multiome 1018
chr19:55,604,520–55,606,690 197.6 kb Distal (>10kb) Multiome 820
chr19:55,623,637–55,625,055 216.7 kb Distal (>10kb) Multiome 650
chr19:55,640,091–55,641,769 233.2 kb Distal (>10kb) Multiome 821
chr19:55,642,197–55,644,356 235.7 kb Distal (>10kb) Multiome 884
chr19:55,647,711–55,648,342 240.3 kb Distal (>10kb) Multiome 671
chr19:55,652,138–55,653,078 244.6 kb Distal (>10kb) Multiome 105
chr19:55,653,199–55,656,056 246.9 kb Distal (>10kb) Multiome 1123
chr19:55,674,767–55,675,613 267.4 kb Distal (>10kb) Multiome 765

Genome Browser

Genomic view of the UBE2S locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:55,107,134 – 55,685,613
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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