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DE-1.35

Submodule 13 genes

Cytoplasmic stress response and protein homeostasis

This module contains 13 genes including GSTP1, CALM1, PPIA, and CFL1, enriched for cytoplasmic stress response and protein homeostasis functions. Knockdown of SOX17 activates this module. Knockdown of SOX11 represses this module.

Key terms: negative regulation of stress-activated MAPK cascade negative regulation of stress-activated protein kinase signaling cascade regulation of stress-activated protein kinase signaling cascade negative regulation of protein metabolic process Notable genes: GSTP1 CALM1 PPIA CFL1 GAPDH PRDX1 PFN1 HSP90AB1 Top TFs: SOX11 SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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