Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GSTP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSTP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSTP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,288,260–67,289,971 | 294.6 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 280.3 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 266.0 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 230.1 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,372,171–67,373,596 | 210.7 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 191.8 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 181.8 kb | Distal (>10kb) Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 162.5 kb | Distal (>10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 155.3 kb | Distal (>10kb) Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 140.1 kb | Distal (>10kb) Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 119.0 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 114.4 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 100.6 kb | Distal (>10kb) Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 77.4 kb | Distal (>10kb) Multiome | 769 | |
| chr11:67,507,504–67,509,030 | 75.4 kb | Distal (>10kb) Multiome | 897 | |
| chr11:67,581,534–67,581,849 | 1.9 kb | Proximal (<10kb) | 133 | |
| chr11:67,583,474–67,584,777 | 16 bp | At TSS Multiome | 633 | |
| chr11:67,606,302–67,607,213 | 23.1 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,614,064–67,614,626 | 30.5 kb | Distal (>10kb) Multiome | 383 | |
| chr11:67,619,429–67,620,391 | 36.1 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 46.7 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:67,757,971–67,758,804 | 174.6 kb | Distal (>10kb) Multiome | 61 | |
| chr11:67,804,576–67,806,617 | 221.9 kb | Distal (>10kb) Multiome | 372 |
Genomic view of the GSTP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.