PPIA

peptidylprolyl isomerase A | CYPA

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.35 Developmental clusters: GC5

Biological processes 61 terms

RNA binding (GO:0003723)activation of protein kinase B activity (GO:0032148)apoptotic process (GO:0006915)apoptotic process (GO:0006915)cell adhesion molecule production (GO:0060352)cellular response to oxidative stress (GO:0034599)cyclosporin A binding (GO:0016018)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)endothelial cell activation (GO:0042118)extracellular exosome (GO:0070062)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)focal adhesion (GO:0005925)heparan sulfate binding (GO:1904399)integrin binding (GO:0005178)leukocyte chemotaxis (GO:0030595)lipid droplet organization (GO:0034389)membrane (GO:0016020)negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)negative regulation of protein K48-linked ubiquitination (GO:0061944)negative regulation of protein kinase activity (GO:0006469)negative regulation of protein phosphorylation (GO:0001933)negative regulation of stress-activated MAPK cascade (GO:0032873)negative regulation of viral life cycle (GO:1903901)neutrophil chemotaxis (GO:0030593)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)peptidyl-prolyl cis-trans isomerase activity (GO:0003755)plasma membrane (GO:0005886)platelet activation (GO:0030168)platelet aggregation (GO:0070527)positive regulation of MAPK cascade (GO:0043410)positive regulation of protein phosphorylation (GO:0001934)positive regulation of protein secretion (GO:0050714)positive regulation of viral genome replication (GO:0045070)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein peptidyl-prolyl isomerization (GO:0000413)protein-containing complex (GO:0032991)regulation of apoptotic signaling pathway (GO:2001233)regulation of viral genome replication (GO:0045069)regulation of viral genome replication (GO:0045069)secretory granule lumen (GO:0034774)unfolded protein binding (GO:0051082)vesicle (GO:0031982)viral release from host cell (GO:0019076)virion binding (GO:0046790)

Expression (TPM)

TFs regulating PPIA 0 TFs

Transcription factors with Perturb-seq knockdown data for PPIA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPIA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPIA

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPIA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:44,573,627–44,574,398	222.7 kb	Distal (>10kb) Multiome	885
chr7:44,581,475–44,583,147	214.3 kb	Distal (>10kb) Multiome HiCAR	864
chr7:44,606,125–44,607,487	189.9 kb	Distal (>10kb) Multiome	1043
chr7:44,748,085–44,749,703	48.1 kb	Distal (>10kb) Multiome	665
chr7:44,795,796–44,797,747	123 bp	At TSS Multiome	1094
chr7:44,847,376–44,848,800	51.5 kb	Distal (>10kb) Multiome	990
chr7:44,884,668–44,886,169	88.9 kb	Distal (>10kb) Multiome	956
chr7:44,962,460–44,963,298	166.2 kb	Distal (>10kb) Multiome	179
chr7:44,986,037–44,987,077	190.0 kb	Distal (>10kb) Multiome	748
chr7:44,999,127–45,000,858	203.3 kb	Distal (>10kb) Multiome	706
chr7:45,051,984–45,052,624	255.6 kb	Distal (>10kb) Multiome	90
chr7:45,088,228–45,089,744	292.5 kb	Distal (>10kb) Multiome	375

Genome Browser

Genomic view of the PPIA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.