HSP90AB1
heat shock protein 90 alpha family class B member 1 | HSPC2, HSPCB

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

Member of: DE-1 DE-1.35 Developmental clusters: GC4
Biological processes 112 terms
ATP binding (GO:0005524)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP-dependent protein binding (GO:0043008)ATP-dependent protein folding chaperone (GO:0140662)COP9 signalosome (GO:0008180)DNA polymerase binding (GO:0070182)DNA polymerase binding (GO:0070182)HSP90-CDC37 chaperone complex (GO:1990565)HSP90-CDC37 chaperone complex (GO:1990565)MHC class II protein complex binding (GO:0023026)RNA binding (GO:0003723)TPR domain binding (GO:0030911)aryl hydrocarbon receptor complex (GO:0034751)axonal growth cone (GO:0044295)axonal growth cone (GO:0044295)cadherin binding (GO:0045296)cell surface (GO:0009986)cellular response to heat (GO:0034605)cellular response to heat (GO:0034605)chaperone-mediated protein complex assembly (GO:0051131)chaperone-mediated protein complex assembly (GO:0051131)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)dendritic growth cone (GO:0044294)dendritic growth cone (GO:0044294)disordered domain specific binding (GO:0097718)disordered domain specific binding (GO:0097718)double-stranded RNA binding (GO:0003725)dynein axonemal particle (GO:0120293)dynein axonemal particle (GO:0120293)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)ficolin-1-rich granule lumen (GO:1904813)heat shock protein binding (GO:0031072)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)histone methyltransferase binding (GO:1990226)identical protein binding (GO:0042802)kinase binding (GO:0019900)kinase binding (GO:0019900)melanosome (GO:0042470)membrane (GO:0016020)mitochondrion (GO:0005739)negative regulation of proteasomal protein catabolic process (GO:1901799)negative regulation of proteasomal protein catabolic process (GO:1901799)negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)nitric-oxide synthase regulator activity (GO:0030235)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)peptide binding (GO:0042277)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cell differentiation (GO:0045597)positive regulation of nitric oxide biosynthetic process (GO:0045429)positive regulation of protein localization to cell surface (GO:2000010)positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein folding chaperone complex (GO:0101031)protein folding chaperone complex (GO:0101031)protein homodimerization activity (GO:0042803)protein kinase binding (GO:0019901)protein kinase regulator activity (GO:0019887)protein phosphatase activator activity (GO:0072542)protein stabilization (GO:0050821)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)receptor ligand inhibitor activity (GO:0141069)regulation of cell cycle (GO:0051726)regulation of protein localization (GO:0032880)regulation of protein localization (GO:0032880)regulation of protein ubiquitination (GO:0031396)regulation of protein ubiquitination (GO:0031396)response to unfolded protein (GO:0006986)secretory granule lumen (GO:0034774)secretory granule lumen (GO:0034774)supramolecular fiber organization (GO:0097435)tau protein binding (GO:0048156)tau protein binding (GO:0048156)telomerase holoenzyme complex assembly (GO:1905323)telomerase holoenzyme complex assembly (GO:1905323)telomere maintenance via telomerase (GO:0007004)telomere maintenance via telomerase (GO:0007004)ubiquitin protein ligase binding (GO:0031625)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)virion attachment to host cell (GO:0019062)
Expression (TPM)
HSP90AB1 — as a Regulated Gene

TFs regulating HSP90AB1 0 TFs

Transcription factors with Perturb-seq knockdown data for HSP90AB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSP90AB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HSP90AB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSP90AB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:43,951,107–43,951,921 295.7 kb Distal (>10kb) Multiome 591
chr6:44,002,061–44,003,708 244.4 kb Distal (>10kb) Multiome 581
chr6:44,126,767–44,128,943 119.6 kb Distal (>10kb) Multiome 845
chr6:44,151,741–44,152,312 95.1 kb Distal (>10kb) Multiome HiCAR 575
chr6:44,185,920–44,186,571 60.9 kb Distal (>10kb) Multiome 95
chr6:44,202,490–44,203,242 44.3 kb Distal (>10kb) Multiome 229
chr6:44,216,763–44,217,285 30.1 kb Distal (>10kb) Multiome 139
chr6:44,218,945–44,220,120 27.5 kb Distal (>10kb) Multiome 799
chr6:44,223,166–44,224,465 23.4 kb Distal (>10kb) Multiome 783
chr6:44,234,203–44,235,350 12.3 kb Distal (>10kb) Multiome 499
chr6:44,237,380–44,238,386 9.2 kb Proximal (<10kb) Multiome 969
chr6:44,245,610–44,248,192 896 bp At TSS Multiome 1271
chr6:44,254,609–44,255,697 7.5 kb Proximal (<10kb) 430
chr6:44,256,209–44,258,064 10.3 kb Distal (>10kb) Multiome 1042
chr6:44,264,892–44,265,788 18.4 kb Distal (>10kb) Multiome 760
chr6:44,270,373–44,271,349 23.9 kb Distal (>10kb) Multiome 166
chr6:44,275,626–44,276,572 28.9 kb Distal (>10kb) Multiome 330
chr6:44,297,234–44,298,035 50.6 kb Distal (>10kb) Multiome 356
chr6:44,312,866–44,313,523 66.2 kb Distal (>10kb) Multiome 1073
chr6:44,342,481–44,342,962 95.6 kb Distal (>10kb) Multiome 133
chr6:44,387,185–44,388,395 140.6 kb Distal (>10kb) Multiome 955
chr6:44,469,799–44,470,296 222.9 kb Distal (>10kb) Multiome 375
chr6:44,475,548–44,476,402 228.8 kb Distal (>10kb) Multiome 587
chr6:44,542,501–44,543,177 295.8 kb Distal (>10kb) Multiome 93

Genome Browser

Genomic view of the HSP90AB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:43,941,107 – 44,553,177
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact