This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for PRDX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,303,203–45,304,881 | 218.1 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:45,315,837–45,316,870 | 205.8 kb | Distal (>10kb) Multiome | 113 | |
| chr1:45,317,165–45,317,643 | 204.4 kb | Distal (>10kb) Multiome | 7 | |
| chr1:45,321,623–45,322,180 | 200.1 kb | Distal (>10kb) Multiome | 54 | |
| chr1:45,326,327–45,328,092 | 195.0 kb | Distal (>10kb) Multiome | 382 | |
| chr1:45,339,505–45,340,694 | 181.8 kb | Distal (>10kb) Multiome | 951 | |
| chr1:45,490,605–45,491,773 | 30.6 kb | Distal (>10kb) Multiome | 900 | |
| chr1:45,499,499–45,500,620 | 21.7 kb | Distal (>10kb) Multiome | 831 | |
| chr1:45,512,677–45,513,157 | 8.7 kb | Proximal (<10kb) | 343 | |
| chr1:45,513,592–45,514,064 | 7.8 kb | Proximal (<10kb) | 15 | |
| chr1:45,521,163–45,522,604 | 91 bp | At TSS Multiome | 1155 | |
| chr1:45,522,743–45,523,047 | 859 bp | At TSS | 134 | |
| chr1:45,550,427–45,551,304 | 29.0 kb | Distal (>10kb) Multiome | 1006 | |
| chr1:45,583,145–45,585,182 | 62.8 kb | Distal (>10kb) Multiome | 997 | |
| chr1:45,622,461–45,623,374 | 101.2 kb | Distal (>10kb) Multiome | 169 | |
| chr1:45,686,052–45,687,740 | 165.2 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:45,687,860–45,688,505 | 166.5 kb | Distal (>10kb) Multiome | 861 | |
| chr1:45,750,186–45,751,093 | 228.8 kb | Distal (>10kb) Multiome | 961 | |
| chr1:45,802,824–45,804,412 | 281.7 kb | Distal (>10kb) Multiome | 753 |
Genomic view of the PRDX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.