This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]
Transcription factors with Perturb-seq knockdown data for CALM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CALM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CALM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:90,204,480–90,205,107 | 192.3 kb | Distal (>10kb) Multiome | 34 | |
| chr14:90,235,195–90,235,657 | 161.6 kb | Distal (>10kb) Multiome | 401 | |
| chr14:90,256,406–90,256,862 | 140.4 kb | Distal (>10kb) Multiome | 718 | |
| chr14:90,331,584–90,332,424 | 65.0 kb | Distal (>10kb) Multiome | 791 | |
| chr14:90,345,568–90,346,463 | 50.9 kb | Distal (>10kb) Multiome | 289 | |
| chr14:90,382,634–90,384,382 | 13.7 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:90,396,430–90,398,792 | 123 bp | At TSS Multiome | 1151 | |
| chr14:90,399,397–90,399,863 | 2.7 kb | Proximal (<10kb) Multiome | 555 | |
| chr14:90,454,113–90,454,877 | 57.5 kb | Distal (>10kb) Multiome | 239 | |
| chr14:90,605,311–90,605,782 | 208.6 kb | Distal (>10kb) Multiome | 80 |
Genomic view of the CALM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.