This module contains 16 genes including LMAN1, SPINT1, PYCR1, SEC61A1, and CRB3, with enrichment in endoplasmic reticulum to Golgi vesicle-mediated transport, Golgi vesicle transport, and Golgi membrane components. Knockdown of SMAD5 and DR1 represses this module, suggesting these transcription factors normally promote its expression during ESC-to-definitive endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.