This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for SLC35A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,676,132–48,677,132 | 235.1 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 215.0 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 174.3 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 109.8 kb | Distal (>10kb) Multiome | 734 | |
| chrX:48,891,080–48,891,988 | 19.9 kb | Distal (>10kb) Multiome | 525 | |
| chrX:48,897,163–48,898,345 | 13.8 kb | Distal (>10kb) Multiome | 672 | |
| chrX:48,911,574–48,912,414 | 319 bp | At TSS Multiome | 671 | |
| chrX:48,917,179–48,917,999 | 5.8 kb | Proximal (<10kb) Multiome | 468 | |
| chrX:48,918,412–48,919,792 | 7.5 kb | Proximal (<10kb) Multiome | 693 | |
| chrX:48,921,656–48,922,006 | 10.0 kb | Proximal (<10kb) | 22 | |
| chrX:48,957,469–48,959,105 | 46.7 kb | Distal (>10kb) Multiome | 722 | |
| chrX:49,001,538–49,002,676 | 90.7 kb | Distal (>10kb) Multiome | 540 | |
| chrX:49,039,840–49,040,493 | 128.4 kb | Distal (>10kb) Multiome | 436 | |
| chrX:49,042,954–49,044,182 | 132.0 kb | Distal (>10kb) Multiome | 664 | |
| chrX:49,053,328–49,054,050 | 142.0 kb | Distal (>10kb) Multiome | 403 | |
| chrX:49,071,863–49,072,612 | 160.4 kb | Distal (>10kb) Multiome | 107 | |
| chrX:49,073,903–49,074,451 | 162.4 kb | Distal (>10kb) Multiome | 464 | |
| chrX:49,100,885–49,101,855 | 189.6 kb | Distal (>10kb) Multiome | 562 | |
| chrX:49,155,633–49,156,658 | 244.5 kb | Distal (>10kb) Multiome | 524 | |
| chrX:49,163,555–49,164,377 | 252.4 kb | Distal (>10kb) Multiome | 485 | |
| chrX:49,166,140–49,166,713 | 254.8 kb | Distal (>10kb) Multiome | 416 | |
| chrX:49,184,219–49,185,254 | 272.9 kb | Distal (>10kb) Multiome | 389 | |
| chrX:49,186,113–49,186,660 | 274.8 kb | Distal (>10kb) Multiome | 589 | |
| chrX:49,190,730–49,191,899 | 279.5 kb | Distal (>10kb) Multiome | 636 | |
| chrX:49,199,793–49,200,448 | 288.5 kb | Distal (>10kb) Multiome | 806 |
Genomic view of the SLC35A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.