This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for CRB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,199,134–6,200,121 | 264.6 kb | Distal (>10kb) Multiome | 769 | |
| chr19:6,279,539–6,280,376 | 184.2 kb | Distal (>10kb) Multiome | 761 | |
| chr19:6,361,350–6,362,018 | 102.7 kb | Distal (>10kb) Multiome | 803 | |
| chr19:6,372,272–6,374,427 | 90.8 kb | Distal (>10kb) Multiome | 925 | |
| chr19:6,392,902–6,394,077 | 70.8 kb | Distal (>10kb) Multiome | 767 | |
| chr19:6,423,613–6,425,899 | 39.1 kb | Distal (>10kb) Multiome | 956 | |
| chr19:6,458,960–6,460,940 | 3.9 kb | Proximal (<10kb) Multiome | 859 | |
| chr19:6,463,863–6,464,838 | 42 bp | At TSS Multiome | 526 | |
| chr19:6,470,903–6,471,589 | 7.0 kb | Proximal (<10kb) Multiome | 26 | |
| chr19:6,475,386–6,477,353 | 12.3 kb | Distal (>10kb) Multiome | 419 | |
| chr19:6,515,952–6,517,331 | 51.9 kb | Distal (>10kb) Multiome | 732 | |
| chr19:6,530,842–6,531,584 | 66.7 kb | Distal (>10kb) Multiome | 640 | |
| chr19:6,551,766–6,552,224 | 87.8 kb | Distal (>10kb) Multiome | 403 | |
| chr19:6,656,104–6,656,671 | 192.2 kb | Distal (>10kb) Multiome | 10 | |
| chr19:6,661,103–6,661,799 | 197.3 kb | Distal (>10kb) Multiome | 83 | |
| chr19:6,718,413–6,719,236 | 254.7 kb | Distal (>10kb) Multiome | 284 | |
| chr19:6,729,971–6,731,015 | 266.3 kb | Distal (>10kb) Multiome | 470 | |
| chr19:6,736,423–6,741,197 | 273.4 kb | Distal (>10kb) Multiome | 1129 | |
| chr19:6,752,403–6,754,362 | 289.5 kb | Distal (>10kb) Multiome | 886 | |
| chr19:7,500,843–7,501,401 | 1036.9 kb | Distal (>10kb) Multiome HiCAR | 556 | |
| chr19:7,505,850–7,507,270 | 1042.3 kb | Distal (>10kb) Multiome HiCAR | 516 |
Genomic view of the CRB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.