PYCR1

pyrroline-5-carboxylate reductase 1 | P5C

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Member of: DE-1 DE-1.32 Developmental clusters: GC3

Biological processes 19 terms

L-proline biosynthetic process (GO:0055129)L-proline biosynthetic process (GO:0055129)L-proline biosynthetic process (GO:0055129)L-proline biosynthetic process (GO:0055129)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)identical protein binding (GO:0042802)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903377)protein binding (GO:0005515)pyrroline-5-carboxylate reductase activity (GO:0004735)pyrroline-5-carboxylate reductase activity (GO:0004735)pyrroline-5-carboxylate reductase activity (GO:0004735)pyrroline-5-carboxylate reductase activity (GO:0004735)pyrroline-5-carboxylate reductase complex (GO:1902792)regulation of mitochondrial membrane potential (GO:0051881)

Expression (TPM)

TFs regulating PYCR1 0 TFs

Transcription factors with Perturb-seq knockdown data for PYCR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PYCR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PYCR1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PYCR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:81,636,404–81,637,301	300.3 kb	Distal (>10kb) Multiome	946
chr17:81,648,048–81,648,550	289.0 kb	Distal (>10kb) Multiome	88
chr17:81,652,970–81,653,572	284.1 kb	Distal (>10kb) Multiome	188
chr17:81,666,251–81,667,166	270.6 kb	Distal (>10kb) Multiome	901
chr17:81,683,344–81,684,556	253.4 kb	Distal (>10kb) Multiome	926
chr17:81,702,879–81,703,868	233.9 kb	Distal (>10kb) Multiome	981
chr17:81,711,721–81,712,812	225.1 kb	Distal (>10kb) Multiome	1056
chr17:81,832,473–81,833,976	104.0 kb	Distal (>10kb) Multiome	1015
chr17:81,859,762–81,861,595	76.5 kb	Distal (>10kb) Multiome	1134
chr17:81,868,421–81,868,978	68.7 kb	Distal (>10kb) Multiome	577
chr17:81,869,000–81,872,289	66.0 kb	Distal (>10kb) Multiome	1136
chr17:81,891,143–81,892,257	45.5 kb	Distal (>10kb) Multiome	969
chr17:81,910,443–81,911,980	25.7 kb	Distal (>10kb) Multiome	806
chr17:81,917,586–81,918,522	19.1 kb	Distal (>10kb) Multiome	619
chr17:81,923,285–81,923,863	13.8 kb	Distal (>10kb) Multiome	399
chr17:81,926,141–81,929,133	9.4 kb	Proximal (<10kb) Multiome	1034
chr17:81,936,855–81,937,682	40 bp	At TSS Multiome	854
chr17:81,959,299–81,962,169	22.4 kb	Distal (>10kb) Multiome	805
chr17:81,966,804–81,968,359	30.8 kb	Distal (>10kb) Multiome	908
chr17:81,976,595–81,978,312	40.4 kb	Distal (>10kb) Multiome	1001
chr17:82,019,856–82,020,391	82.8 kb	Distal (>10kb) Multiome	436
chr17:82,022,355–82,024,111	85.8 kb	Distal (>10kb) Multiome	898
chr17:82,029,976–82,032,662	94.6 kb	Distal (>10kb) Multiome	695
chr17:82,036,902–82,037,961	100.3 kb	Distal (>10kb) Multiome	892
chr17:82,051,387–82,052,184	114.5 kb	Distal (>10kb) Multiome	479
chr17:82,065,558–82,066,150	128.5 kb	Distal (>10kb) Multiome	967
chr17:82,096,478–82,100,203	161.2 kb	Distal (>10kb) Multiome	1085
chr17:82,103,334–82,104,356	166.3 kb	Distal (>10kb) Multiome	672
chr17:82,212,405–82,213,592	275.6 kb	Distal (>10kb) Multiome	911
chr17:82,228,266–82,232,536	291.7 kb	Distal (>10kb) Multiome	1048

Genome Browser

Genomic view of the PYCR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.