The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SPINT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPINT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPINT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,593,777–40,594,776 | 250.0 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 149.0 kb | Distal (>10kb) Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 88.7 kb | Distal (>10kb) Multiome | 816 | |
| chr15:40,763,848–40,764,563 | 80.0 kb | Distal (>10kb) Multiome | 799 | |
| chr15:40,806,990–40,807,956 | 36.5 kb | Distal (>10kb) Multiome | 782 | |
| chr15:40,843,756–40,844,502 | 69 bp | At TSS Multiome | 364 | |
| chr15:40,873,588–40,874,396 | 29.9 kb | Distal (>10kb) Multiome | 556 | |
| chr15:40,893,927–40,894,547 | 50.3 kb | Distal (>10kb) Multiome | 741 | |
| chr15:40,906,419–40,906,902 | 62.5 kb | Distal (>10kb) Multiome | 630 | |
| chr15:40,941,651–40,942,174 | 97.9 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 109.3 kb | Distal (>10kb) Multiome | 618 | |
| chr15:41,115,645–41,116,753 | 272.4 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the SPINT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.