The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for LMAN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMAN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMAN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:59,139,305–59,140,740 | 219.5 kb | Distal (>10kb) Multiome | 767 | |
| chr18:59,176,733–59,177,291 | 182.3 kb | Distal (>10kb) Multiome | 9 | |
| chr18:59,219,767–59,220,751 | 139.0 kb | Distal (>10kb) Multiome | 135 | |
| chr18:59,265,207–59,265,918 | 93.7 kb | Distal (>10kb) Multiome | 139 | |
| chr18:59,268,665–59,269,734 | 90.0 kb | Distal (>10kb) Multiome | 312 | |
| chr18:59,272,354–59,274,393 | 85.8 kb | Distal (>10kb) Multiome | 271 | |
| chr18:59,308,314–59,309,013 | 50.6 kb | Distal (>10kb) Multiome | 405 | |
| chr18:59,358,405–59,359,814 | 79 bp | At TSS Multiome | 877 | |
| chr18:59,386,497–59,387,519 | 27.8 kb | Distal (>10kb) Multiome | 118 | |
| chr18:59,402,363–59,402,995 | 43.3 kb | Distal (>10kb) Multiome HiCAR | 491 | |
| chr18:59,416,052–59,417,110 | 57.2 kb | Distal (>10kb) Multiome | 123 | |
| chr18:59,516,161–59,517,246 | 157.5 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the LMAN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.