DBNL
drebrin like | ABP1, HIP-55, SH3P7

Enables cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-1 DE-1.32 Developmental clusters: GC7
Biological processes 53 terms
Golgi membrane (GO:0000139)Rac protein signal transduction (GO:0016601)actin binding (GO:0003779)actin binding (GO:0003779)actin filament binding (GO:0051015)actin filament binding (GO:0051015)cadherin binding (GO:0045296)cell cortex (GO:0005938)cell cortex (GO:0005938)clathrin-coated vesicle membrane (GO:0030665)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)dendrite (GO:0030425)early endosome (GO:0005769)endocytosis (GO:0006897)enzyme activator activity (GO:0008047)extracellular exosome (GO:0070062)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)glutamatergic synapse (GO:0098978)lamellipodium (GO:0030027)lamellipodium (GO:0030027)membrane (GO:0016020)membrane organization (GO:0061024)neuron projection (GO:0043005)neuron projection morphogenesis (GO:0048812)neuron projection morphogenesis (GO:0048812)perikaryon (GO:0043204)plasma membrane (GO:0005886)plasma membrane (GO:0005886)podosome (GO:0002102)podosome (GO:0002102)podosome assembly (GO:0071800)podosome assembly (GO:0071800)postsynapse (GO:0098794)postsynaptic actin cytoskeleton organization (GO:0098974)postsynaptic density (GO:0014069)presynapse (GO:0098793)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein-macromolecule adaptor activity (GO:0030674)ruffle (GO:0001726)ruffle (GO:0001726)secretory granule lumen (GO:0034774)structural constituent of postsynaptic actin cytoskeleton (GO:0098973)synapse (GO:0045202)synapse assembly (GO:0007416)synapse assembly (GO:0007416)tertiary granule lumen (GO:1904724)
Expression (TPM)
DBNL — as a Regulated Gene

TFs regulating DBNL 0 TFs

Transcription factors with Perturb-seq knockdown data for DBNL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DBNL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to DBNL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DBNL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr7:43,758,058–43,759,333 286.0 kb Distal (>10kb) Multiome 665
chr7:43,838,582–43,839,204 205.7 kb Distal (>10kb) Multiome 647
chr7:43,868,905–43,870,110 175.2 kb Distal (>10kb) Multiome 804
chr7:43,905,962–43,907,078 138.1 kb Distal (>10kb) Multiome 557
chr7:43,926,113–43,927,072 118.2 kb Distal (>10kb) Multiome 1004
chr7:43,985,975–43,986,501 58.4 kb Distal (>10kb) Multiome 113
chr7:44,018,938–44,019,667 25.5 kb Distal (>10kb) Multiome 564
chr7:44,038,952–44,039,494 5.5 kb Proximal (<10kb) Multiome 215
chr7:44,044,335–44,045,323 2 bp At TSS Multiome 832
chr7:44,063,611–44,064,251 19.3 kb Distal (>10kb) Multiome 121
chr7:44,065,163–44,066,086 21.1 kb Distal (>10kb) Multiome 198
chr7:44,081,995–44,083,183 38.0 kb Distal (>10kb) Multiome 909
chr7:44,103,745–44,105,419 59.6 kb Distal (>10kb) Multiome 267
chr7:44,112,627–44,113,466 68.3 kb Distal (>10kb) Multiome 237
chr7:44,123,183–44,124,199 78.9 kb Distal (>10kb) Multiome 814
chr7:44,145,408–44,146,956 101.5 kb Distal (>10kb) Multiome 347
chr7:44,200,748–44,201,465 156.2 kb Distal (>10kb) Multiome 738
chr7:44,218,223–44,218,706 173.7 kb Distal (>10kb) Multiome HiCAR 215
chr7:44,275,748–44,276,529 231.5 kb Distal (>10kb) Multiome 146
chr7:44,309,084–44,310,124 265.1 kb Distal (>10kb) Multiome 263
chr7:44,325,052–44,325,687 280.7 kb Distal (>10kb) Multiome 118

Genome Browser

Genomic view of the DBNL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr7:43,748,058 – 44,335,687
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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