This 19-gene module includes BAD, CD151, CBY1, AGPAT2, and USB1, with top enriched terms in apoptosis, cell death, and membrane organization. Knockdown of SOX17 activates this module, while knockdown of GATA4 and FOXA2 represses it. The module's enrichment in apoptotic pathways suggests a role in regulating cell survival during endoderm specification.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.