This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for TAX1BP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAX1BP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAX1BP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,529,956–3,530,848 | 138.2 kb | Distal (>10kb) Multiome | 320 | |
| chr17:3,535,341–3,536,205 | 132.9 kb | Distal (>10kb) Multiome | 356 | |
| chr17:3,546,350–3,546,812 | 121.9 kb | Distal (>10kb) Multiome | 106 | |
| chr17:3,635,650–3,637,225 | 32.1 kb | Distal (>10kb) Multiome | 866 | |
| chr17:3,667,393–3,669,475 | 55 bp | At TSS Multiome | 949 | |
| chr17:3,723,432–3,724,429 | 55.2 kb | Distal (>10kb) Multiome | 865 | |
| chr17:3,754,197–3,755,835 | 86.3 kb | Distal (>10kb) Multiome | 396 | |
| chr17:3,845,518–3,846,549 | 177.7 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 224.7 kb | Distal (>10kb) Multiome | 716 | |
| chr17:3,944,497–3,945,384 | 276.3 kb | Distal (>10kb) Multiome | 277 | |
| chr17:3,964,969–3,965,418 | 296.7 kb | Distal (>10kb) Multiome | 333 |
Genomic view of the TAX1BP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.