SLC52A2

solute carrier family 52 member 2 | D15Ertd747e, FLJ11856, GPCR41, HuPAR-1, PAR1, RFT3, RFVT2, hRFT3, GPR172A

This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012]

Member of: DE-1 DE-1.21

Biological processes 14 terms

4-hydroxybutyrate receptor activity (GO:0062124)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)riboflavin metabolic process (GO:0006771)riboflavin transmembrane transporter activity (GO:0032217)riboflavin transmembrane transporter activity (GO:0032217)riboflavin transmembrane transporter activity (GO:0032217)riboflavin transmembrane transporter activity (GO:0032217)riboflavin transport (GO:0032218)riboflavin transport (GO:0032218)riboflavin transport (GO:0032218)

Expression (TPM)

TFs regulating SLC52A2 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC52A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC52A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SLC52A2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC52A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:144,060,259–144,061,087	297.8 kb	Distal (>10kb) Multiome	727
chr8:144,078,142–144,079,235	279.9 kb	Distal (>10kb) Multiome	912
chr8:144,082,187–144,083,105	276.0 kb	Distal (>10kb) Multiome	763
chr8:144,094,454–144,095,491	263.6 kb	Distal (>10kb) Multiome	798
chr8:144,103,485–144,105,242	254.3 kb	Distal (>10kb) Multiome	1033
chr8:144,108,038–144,108,663	250.2 kb	Distal (>10kb) Multiome	137
chr8:144,137,565–144,138,500	220.8 kb	Distal (>10kb) Multiome	817
chr8:144,146,820–144,149,073	210.6 kb	Distal (>10kb) Multiome	790
chr8:144,266,293–144,267,098	92.1 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	67.1 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	42.5 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	31.7 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	26.6 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	21.7 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	4.0 kb	Proximal (<10kb) Multiome	280
chr8:144,357,674–144,358,036	555 bp	At TSS	305
chr8:144,358,142–144,359,070	12 bp	At TSS Multiome	719
chr8:144,369,349–144,369,916	11.1 kb	Distal (>10kb) Multiome HiCAR	204
chr8:144,372,497–144,372,883	14.1 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	15.4 kb	Distal (>10kb) Multiome	903
chr8:144,408,968–144,410,189	50.9 kb	Distal (>10kb) Multiome	920
chr8:144,427,691–144,429,571	70.0 kb	Distal (>10kb) Multiome HiCAR	1000
chr8:144,443,691–144,445,047	85.8 kb	Distal (>10kb) Multiome HiCAR	743
chr8:144,462,568–144,463,422	104.3 kb	Distal (>10kb) Multiome	548
chr8:144,463,885–144,468,178	107.2 kb	Distal (>10kb) Multiome	910
chr8:144,471,960–144,474,391	114.0 kb	Distal (>10kb) Multiome	482
chr8:144,474,517–144,476,543	117.3 kb	Distal (>10kb) Multiome	321
chr8:144,477,277–144,478,749	119.4 kb	Distal (>10kb) Multiome	679
chr8:144,478,851–144,479,509	120.7 kb	Distal (>10kb) Multiome	392
chr8:144,483,979–144,484,843	125.8 kb	Distal (>10kb) Multiome	125
chr8:144,495,748–144,496,431	137.5 kb	Distal (>10kb) Multiome	131
chr8:144,500,182–144,501,505	142.4 kb	Distal (>10kb) Multiome	484
chr8:144,507,995–144,510,268	150.3 kb	Distal (>10kb) Multiome	1067
chr8:144,517,168–144,518,442	159.3 kb	Distal (>10kb) Multiome	637
chr8:144,521,935–144,523,450	163.9 kb	Distal (>10kb) Multiome	663
chr8:144,524,105–144,525,099	166.1 kb	Distal (>10kb) Multiome	264
chr8:144,526,399–144,529,305	168.5 kb	Distal (>10kb) Multiome	934
chr8:144,529,455–144,530,630	171.6 kb	Distal (>10kb) Multiome	284
chr8:144,580,290–144,581,657	222.2 kb	Distal (>10kb) Multiome	271

Genome Browser

Genomic view of the SLC52A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.