ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARL2BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL2BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL2BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,989,388–56,989,907 | 255.7 kb | Distal (>10kb) Multiome | 646 | |
| chr16:57,092,097–57,093,443 | 152.5 kb | Distal (>10kb) Multiome | 584 | |
| chr16:57,185,577–57,186,853 | 59.1 kb | Distal (>10kb) Multiome | 925 | |
| chr16:57,244,660–57,245,782 | 145 bp | At TSS Multiome | 949 | |
| chr16:57,256,968–57,257,582 | 12.0 kb | Distal (>10kb) Multiome | 94 | |
| chr16:57,284,181–57,285,057 | 39.4 kb | Distal (>10kb) Multiome | 883 | |
| chr16:57,299,458–57,301,365 | 54.7 kb | Distal (>10kb) Multiome | 1112 | |
| chr16:57,416,668–57,417,660 | 171.9 kb | Distal (>10kb) Multiome | 597 | |
| chr16:57,427,202–57,428,139 | 182.4 kb | Distal (>10kb) Multiome | 105 | |
| chr16:57,446,894–57,447,991 | 202.2 kb | Distal (>10kb) Multiome | 958 | |
| chr16:57,462,496–57,462,948 | 217.4 kb | Distal (>10kb) Multiome | 903 | |
| chr16:57,475,764–57,476,257 | 230.8 kb | Distal (>10kb) Multiome | 391 | |
| chr16:57,485,922–57,486,831 | 241.2 kb | Distal (>10kb) Multiome | 527 | |
| chr16:57,528,258–57,529,545 | 283.4 kb | Distal (>10kb) Multiome | 230 | |
| chr16:57,535,588–57,536,986 | 290.9 kb | Distal (>10kb) Multiome | 726 |
Genomic view of the ARL2BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.