This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AGPAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGPAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGPAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,399,639–136,400,642 | 287.2 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,410,307–136,410,943 | 276.8 kb | Distal (>10kb) Multiome | 740 | |
| chr9:136,438,826–136,440,227 | 247.6 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 204.0 kb | Distal (>10kb) Multiome | 938 | |
| chr9:136,545,392–136,547,129 | 141.3 kb | Distal (>10kb) Multiome | 710 | |
| chr9:136,572,053–136,572,865 | 115.1 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 99.0 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 60.5 kb | Distal (>10kb) Multiome | 451 | |
| chr9:136,665,223–136,666,507 | 21.5 kb | Distal (>10kb) Multiome HiCAR | 409 | |
| chr9:136,686,875–136,688,079 | 90 bp | At TSS Multiome | 610 | |
| chr9:136,694,292–136,694,457 | 6.9 kb | Proximal (<10kb) | 313 | |
| chr9:136,711,795–136,713,743 | 25.0 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,727,616–136,729,079 | 40.8 kb | Distal (>10kb) Multiome | 1013 | |
| chr9:136,762,846–136,763,902 | 75.8 kb | Distal (>10kb) Multiome | 271 | |
| chr9:136,788,889–136,789,680 | 101.9 kb | Distal (>10kb) Multiome | 351 | |
| chr9:136,790,433–136,792,285 | 103.7 kb | Distal (>10kb) Multiome | 864 | |
| chr9:136,798,823–136,801,421 | 113.9 kb | Distal (>10kb) Multiome | 874 | |
| chr9:136,807,251–136,808,764 | 120.5 kb | Distal (>10kb) Multiome | 714 | |
| chr9:136,842,325–136,842,872 | 155.1 kb | Distal (>10kb) Multiome | 492 | |
| chr9:136,846,187–136,850,214 | 162.0 kb | Distal (>10kb) Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 179.0 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 199.0 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 257.3 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 262.8 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 291.1 kb | Distal (>10kb) Multiome | 413 |
Genomic view of the AGPAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.