The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CD151. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD151 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD151, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:534,525–536,399 | 297.3 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 295.5 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 277.8 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 272.1 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 264.4 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 256.8 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 219.2 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 217.0 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 195.8 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 137.5 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 126.9 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 112.1 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 104.8 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 85.6 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 69.7 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 55.5 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 49.2 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 34.7 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 27.6 kb | Distal (>10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 23.2 kb | Distal (>10kb) Multiome | 976 | |
| chr11:818,369–820,592 | 13.4 kb | Distal (>10kb) Multiome | 749 | |
| chr11:826,980–828,116 | 5.4 kb | Proximal (<10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 2.6 kb | Proximal (<10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 82 bp | At TSS Multiome | 562 | |
| chr11:842,034–843,556 | 9.7 kb | Proximal (<10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 11.5 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 16.8 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 78.0 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 92.9 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the CD151 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.