Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CBY1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CBY1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CBY1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,674,916–37,675,641 | 981.3 kb | Distal (>10kb) Multiome HiCAR | 607 | |
| chr22:37,676,590–37,677,674 | 979.4 kb | Distal (>10kb) Multiome HiCAR | 655 | |
| chr22:38,397,757–38,399,352 | 257.7 kb | Distal (>10kb) Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 200.6 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 195.0 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 150.1 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 86.3 kb | Distal (>10kb) Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 157 bp | At TSS Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 25.3 kb | Distal (>10kb) Multiome | 947 | |
| chr22:38,700,377–38,701,744 | 44.3 kb | Distal (>10kb) Multiome | 916 | |
| chr22:38,705,151–38,706,595 | 49.1 kb | Distal (>10kb) Multiome | 821 | |
| chr22:38,755,428–38,756,383 | 99.4 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 137.5 kb | Distal (>10kb) Multiome | 484 | |
| chr22:38,843,207–38,844,443 | 187.2 kb | Distal (>10kb) Multiome | 585 | |
| chr22:38,866,394–38,866,832 | 209.9 kb | Distal (>10kb) Multiome | 76 | |
| chr22:38,871,208–38,873,237 | 215.7 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the CBY1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.