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DE-1.11

Submodule 30 genes

Vacuolar organization and lysosomal function

This 30-gene module includes TIMP1, GRN, KCNQ2, PLTP, and EGFL7, with enrichment in vacuole-related processes. Knockdown of DNAJC19, SOX17, and FOXH1 activates this module. Knockdown of SOX4 and SOX11 represses this module.

Key terms: nicotinamide nucleotide biosynthetic process NAD+ biosynthetic process pyridine nucleotide biosynthetic process carboxylic acid catabolic process Notable genes: TIMP1 GRN KCNQ2 PLTP EGFL7 ARL6IP5 FKBP8 CCS Top TFs: DNAJC19 SOX17 SOX4 SOX11 FOXH1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (30)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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