Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARL6IP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL6IP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL6IP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:67,653,783–67,655,256 | 1430.4 kb | Distal (>10kb) Multiome HiCAR | 862 | |
| chr3:68,931,297–68,933,078 | 152.4 kb | Distal (>10kb) Multiome | 419 | |
| chr3:69,012,112–69,014,102 | 71.4 kb | Distal (>10kb) Multiome | 935 | |
| chr3:69,079,501–69,080,755 | 4.7 kb | Proximal (<10kb) Multiome | 569 | |
| chr3:69,084,409–69,085,904 | 38 bp | At TSS Multiome | 707 | |
| chr3:69,086,247–69,086,655 | 1.2 kb | Proximal (<10kb) | 273 | |
| chr3:69,288,126–69,288,883 | 203.5 kb | Distal (>10kb) Multiome | 254 | |
| chr3:69,290,108–69,290,999 | 205.6 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the ARL6IP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.