The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLTP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLTP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLTP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:45,764,655–45,765,666 | 147.1 kb | Distal (>10kb) Multiome | 192 | |
| chr20:45,770,709–45,771,657 | 140.9 kb | Distal (>10kb) Multiome | 436 | |
| chr20:45,791,633–45,792,259 | 120.2 kb | Distal (>10kb) Multiome | 882 | |
| chr20:45,812,087–45,813,052 | 99.7 kb | Distal (>10kb) Multiome | 695 | |
| chr20:45,833,493–45,834,622 | 78.2 kb | Distal (>10kb) Multiome | 833 | |
| chr20:45,856,871–45,858,137 | 54.6 kb | Distal (>10kb) Multiome | 884 | |
| chr20:45,880,796–45,881,524 | 31.0 kb | Distal (>10kb) Multiome | 738 | |
| chr20:45,890,127–45,891,800 | 20.8 kb | Distal (>10kb) Multiome | 1095 | |
| chr20:45,910,538–45,912,397 | 121 bp | At TSS Multiome | 713 | |
| chr20:45,933,591–45,935,780 | 23.0 kb | Distal (>10kb) Multiome | 1195 | |
| chr20:45,971,553–45,972,790 | 60.0 kb | Distal (>10kb) Multiome | 1206 | |
| chr20:46,004,647–46,005,315 | 92.8 kb | Distal (>10kb) Multiome | 207 | |
| chr20:46,011,604–46,012,166 | 99.8 kb | Distal (>10kb) Multiome | 239 | |
| chr20:46,013,565–46,014,586 | 102.0 kb | Distal (>10kb) Multiome | 735 | |
| chr20:46,021,209–46,023,166 | 109.8 kb | Distal (>10kb) Multiome | 679 | |
| chr20:46,031,750–46,032,261 | 119.9 kb | Distal (>10kb) Multiome | 227 | |
| chr20:46,058,408–46,058,983 | 146.6 kb | Distal (>10kb) Multiome | 123 | |
| chr20:46,089,092–46,090,355 | 177.7 kb | Distal (>10kb) Multiome | 1047 | |
| chr20:46,091,736–46,092,300 | 180.1 kb | Distal (>10kb) Multiome | 38 | |
| chr20:46,117,897–46,118,755 | 206.1 kb | Distal (>10kb) Multiome | 376 | |
| chr20:46,174,457–46,175,011 | 262.6 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the PLTP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.