This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for EGFL7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EGFL7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EGFL7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,342,464–136,343,245 | 323.0 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr9:136,362,899–136,364,677 | 302.5 kb | Distal (>10kb) Multiome HiCAR | 969 | |
| chr9:136,399,639–136,400,642 | 265.5 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,410,307–136,410,943 | 255.2 kb | Distal (>10kb) Multiome HiCAR | 740 | |
| chr9:136,438,826–136,440,227 | 225.9 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 182.4 kb | Distal (>10kb) Multiome | 938 | |
| chr9:136,545,392–136,547,129 | 119.7 kb | Distal (>10kb) Multiome | 710 | |
| chr9:136,572,053–136,572,865 | 93.5 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 77.4 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 38.9 kb | Distal (>10kb) Multiome | 451 | |
| chr9:136,665,223–136,666,507 | 67 bp | At TSS Multiome | 409 | |
| chr9:136,686,875–136,688,079 | 21.7 kb | Distal (>10kb) Multiome HiCAR | 610 | |
| chr9:136,711,795–136,713,743 | 46.6 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,727,616–136,729,079 | 62.4 kb | Distal (>10kb) Multiome | 1013 | |
| chr9:136,762,846–136,763,902 | 97.4 kb | Distal (>10kb) Multiome | 271 | |
| chr9:136,788,889–136,789,680 | 123.5 kb | Distal (>10kb) Multiome | 351 | |
| chr9:136,790,433–136,792,285 | 125.3 kb | Distal (>10kb) Multiome | 864 | |
| chr9:136,798,823–136,801,421 | 135.6 kb | Distal (>10kb) Multiome | 874 | |
| chr9:136,807,251–136,808,764 | 142.1 kb | Distal (>10kb) Multiome | 714 | |
| chr9:136,842,325–136,842,872 | 176.7 kb | Distal (>10kb) Multiome | 492 | |
| chr9:136,846,187–136,850,214 | 183.6 kb | Distal (>10kb) Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 200.6 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 220.6 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 278.9 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 284.4 kb | Distal (>10kb) Multiome | 776 |
Genomic view of the EGFL7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.