CCS
copper chaperone for superoxide dismutase

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.11 Developmental clusters: GC6
Biological processes 18 terms
cadherin binding (GO:0045296)cellular response to oxidative stress (GO:0034599)copper ion binding (GO:0005507)copper ion binding (GO:0005507)copper ion binding (GO:0005507)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)metal ion binding (GO:0046872)mitochondrion (GO:0005739)nucleus (GO:0005634)protein binding (GO:0005515)protein maturation (GO:0051604)protein-disulfide reductase activity (GO:0015035)removal of superoxide radicals (GO:0019430)removal of superoxide radicals (GO:0019430)superoxide dismutase copper chaperone activity (GO:0016532)superoxide metabolic process (GO:0006801)
Expression (TPM)
CCS — as a Regulated Gene

TFs regulating CCS 0 TFs

Transcription factors with Perturb-seq knockdown data for CCS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CCS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:66,311,658–66,313,958 281.0 kb Distal (>10kb) Multiome 1005
chr11:66,316,861–66,317,347 276.1 kb Distal (>10kb) Multiome 164
chr11:66,328,223–66,328,781 264.6 kb Distal (>10kb) Multiome 662
chr11:66,344,804–66,345,488 248.0 kb Distal (>10kb) Multiome 731
chr11:66,347,078–66,348,463 245.3 kb Distal (>10kb) Multiome 866
chr11:66,370,733–66,372,576 221.3 kb Distal (>10kb) Multiome 800
chr11:66,408,467–66,409,206 184.4 kb Distal (>10kb) Multiome 569
chr11:66,421,258–66,422,129 171.4 kb Distal (>10kb) Multiome 1190
chr11:66,438,544–66,439,241 154.2 kb Distal (>10kb) Multiome 756
chr11:66,466,155–66,467,634 126.3 kb Distal (>10kb) Multiome 579
chr11:66,479,578–66,480,947 112.8 kb Distal (>10kb) Multiome 937
chr11:66,510,277–66,510,954 82.5 kb Distal (>10kb) Multiome 787
chr11:66,545,631–66,547,072 47.0 kb Distal (>10kb) Multiome 753
chr11:66,568,061–66,568,910 24.6 kb Distal (>10kb) Multiome 392
chr11:66,592,561–66,593,452 91 bp At TSS Multiome 857
chr11:66,616,078–66,617,408 23.4 kb Distal (>10kb) Multiome 1011
chr11:66,637,919–66,639,003 45.4 kb Distal (>10kb) Multiome 872
chr11:66,677,182–66,678,796 84.8 kb Distal (>10kb) Multiome 926
chr11:66,728,259–66,728,943 135.3 kb Distal (>10kb) Multiome 275
chr11:66,744,354–66,745,291 151.6 kb Distal (>10kb) Multiome 747
chr11:66,842,896–66,843,952 250.3 kb Distal (>10kb) Multiome 843
chr11:66,855,758–66,857,980 263.2 kb Distal (>10kb) Multiome 795
chr11:66,882,995–66,883,462 290.1 kb Distal (>10kb) Multiome 277

Genome Browser

Genomic view of the CCS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:66,301,658 – 66,893,462
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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