This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TIMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,321,409–47,321,883 | 260.8 kb | Distal (>10kb) Multiome | 127 | |
| chrX:47,361,756–47,362,456 | 220.3 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 200.2 kb | Distal (>10kb) Multiome | 17 | |
| chrX:47,482,474–47,483,311 | 99.6 kb | Distal (>10kb) Multiome | 573 | |
| chrX:47,523,425–47,523,870 | 58.8 kb | Distal (>10kb) Multiome | 403 | |
| chrX:47,556,126–47,556,602 | 26.1 kb | Distal (>10kb) Multiome | 278 | |
| chrX:47,560,759–47,561,636 | 21.2 kb | Distal (>10kb) Multiome | 638 | |
| chrX:47,573,672–47,573,925 | 8.5 kb | Proximal (<10kb) | 93 | |
| chrX:47,574,878–47,575,160 | 7.2 kb | Proximal (<10kb) | 44 | |
| chrX:47,582,138–47,582,576 | at TSS | At TSS | 497 | |
| chrX:47,619,457–47,620,174 | 37.5 kb | Distal (>10kb) Multiome | 643 | |
| chrX:47,623,578–47,624,031 | 41.5 kb | Distal (>10kb) Multiome | 183 | |
| chrX:47,650,269–47,651,363 | 68.4 kb | Distal (>10kb) Multiome | 552 | |
| chrX:47,658,568–47,659,484 | 76.6 kb | Distal (>10kb) Multiome | 753 | |
| chrX:47,836,213–47,837,023 | 254.3 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the TIMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.