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DE-1.10

Submodule 33 genes

Cytosolic ribosomal and mitochondrial metabolism module

This 33-gene module includes ATOX1, ROMO1, RPS27, DSTN, and SLIRP, with strong enrichment for ribosomal structure and function, cytoplasmic translation, and oxidative phosphorylation pathways. Knockdown of ARID1A activates this module. Knockdown of SOX11, SMAD5, KLF8, and DR1 represses this module.

Key terms: cytoplasmic translation oxidative phosphorylation aerobic respiration cellular respiration Notable genes: ATOX1 ROMO1 RPS27 DSTN SLIRP UBL5 COX6C TOMM7 Top TFs: ARID1A SOX11 SMAD5 KLF8 DR1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (33)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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