This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATOX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATOX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATOX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:151,496,053–151,496,694 | 262.3 kb | Distal (>10kb) Multiome | 64 | |
| chr5:151,500,606–151,501,090 | 257.7 kb | Distal (>10kb) Multiome | 332 | |
| chr5:151,590,936–151,591,543 | 167.3 kb | Distal (>10kb) Multiome | 83 | |
| chr5:151,658,968–151,659,631 | 99.5 kb | Distal (>10kb) Multiome HiCAR | 335 | |
| chr5:151,673,039–151,674,114 | 85.1 kb | Distal (>10kb) Multiome HiCAR | 193 | |
| chr5:151,684,706–151,685,487 | 73.6 kb | Distal (>10kb) Multiome | 323 | |
| chr5:151,686,404–151,687,445 | 71.6 kb | Distal (>10kb) Multiome | 314 | |
| chr5:151,740,170–151,741,128 | 18.0 kb | Distal (>10kb) Multiome | 315 | |
| chr5:151,757,903–151,759,332 | 62 bp | At TSS Multiome | 766 | |
| chr5:151,770,363–151,773,120 | 13.0 kb | Distal (>10kb) Multiome | 1055 | |
| chr5:151,902,932–151,903,823 | 144.8 kb | Distal (>10kb) Multiome | 181 | |
| chr5:152,051,788–152,052,791 | 293.5 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the ATOX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.