Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLIRP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLIRP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLIRP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:77,456,961–77,458,831 | 250.4 kb | Distal (>10kb) Multiome | 878 | |
| chr14:77,498,012–77,499,509 | 209.2 kb | Distal (>10kb) Multiome | 599 | |
| chr14:77,615,862–77,617,380 | 91.3 kb | Distal (>10kb) Multiome | 892 | |
| chr14:77,654,873–77,655,664 | 52.9 kb | Distal (>10kb) Multiome | 287 | |
| chr14:77,707,585–77,708,371 | 57 bp | At TSS Multiome | 744 | |
| chr14:77,760,384–77,761,929 | 53.0 kb | Distal (>10kb) Multiome | 755 | |
| chr14:77,799,937–77,800,798 | 92.1 kb | Distal (>10kb) Multiome | 865 | |
| chr14:77,965,921–77,966,514 | 258.1 kb | Distal (>10kb) Multiome | 258 | |
| chr14:77,980,545–77,981,614 | 273.0 kb | Distal (>10kb) Multiome | 329 |
Genomic view of the SLIRP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.