This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for UBL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,140,232–9,140,885 | 687.5 kb | Distal (>10kb) Multiome HiCAR | 722 | |
| chr19:9,538,339–9,539,009 | 289.2 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 245.4 kb | Distal (>10kb) Multiome | 99 | |
| chr19:9,584,055–9,584,863 | 243.3 kb | Distal (>10kb) Multiome | 801 | |
| chr19:9,620,792–9,622,027 | 206.6 kb | Distal (>10kb) Multiome | 856 | |
| chr19:9,674,791–9,675,456 | 152.8 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 59.2 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 42.1 kb | Distal (>10kb) Multiome | 727 | |
| chr19:9,791,515–9,793,483 | 35.1 kb | Distal (>10kb) Multiome | 507 | |
| chr19:9,818,302–9,820,113 | 8.6 kb | Proximal (<10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 100 bp | At TSS Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 7.2 kb | Proximal (<10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 85.8 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 86.9 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 106.4 kb | Distal (>10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 108.6 kb | Distal (>10kb) Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 199.9 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 258.4 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 268.4 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 278.4 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 285.3 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 292.0 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the UBL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.