ROMO1

reactive oxygen species modulator 1 | MTGMP, bA353C18.2, C20orf52

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]

Member of: DE-1 DE-1.10 Developmental clusters: GC7

Biological processes 23 terms

TIM23 mitochondrial import inner membrane translocase complex (GO:0005744)TIM23 mitochondrial import inner membrane translocase complex (GO:0005744)antibacterial innate immune response (GO:0140367)antibacterial innate immune response (GO:0140367)cellular response to reactive oxygen species (GO:0034614)defense response to Gram-negative bacterium (GO:0050829)defense response to Gram-negative bacterium (GO:0050829)defense response to Gram-positive bacterium (GO:0050830)defense response to bacterium (GO:0042742)intracellular protein transport (GO:0006886)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion (GO:0005739)monoatomic cation transmembrane transport (GO:0098655)monoatomic cation transmembrane transporter activity (GO:0008324)positive regulation of reactive oxygen species metabolic process (GO:2000379)protein binding (GO:0005515)protein import into mitochondrial matrix (GO:0030150)protein insertion into mitochondrial inner membrane (GO:0045039)protein insertion into mitochondrial inner membrane (GO:0045039)replicative senescence (GO:0090399)

Expression (TPM)

TFs regulating ROMO1 0 TFs

Transcription factors with Perturb-seq knockdown data for ROMO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ROMO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ROMO1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ROMO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:35,454,521–35,455,845	244.2 kb	Distal (>10kb) Multiome	1059
chr20:35,539,672–35,540,321	159.4 kb	Distal (>10kb) Multiome	311
chr20:35,541,280–35,542,685	157.3 kb	Distal (>10kb) Multiome	849
chr20:35,600,739–35,601,999	97.8 kb	Distal (>10kb) Multiome	575
chr20:35,604,921–35,605,589	94.1 kb	Distal (>10kb) Multiome	27
chr20:35,615,559–35,617,919	81.6 kb	Distal (>10kb) Multiome	1169
chr20:35,618,589–35,619,849	79.9 kb	Distal (>10kb) Multiome	865
chr20:35,664,428–35,665,171	34.5 kb	Distal (>10kb) Multiome	1018
chr20:35,698,724–35,699,893	28 bp	At TSS Multiome	1035
chr20:35,741,564–35,742,903	43.0 kb	Distal (>10kb) Multiome	1145
chr20:35,769,101–35,769,560	69.9 kb	Distal (>10kb) Multiome	415
chr20:35,771,622–35,772,463	72.7 kb	Distal (>10kb) Multiome	998
chr20:35,953,663–35,955,230	255.2 kb	Distal (>10kb) Multiome	1166

Genome Browser

Genomic view of the ROMO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.