Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for COX6C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX6C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX6C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:98,169,855–98,170,713 | 1723.4 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr8:99,892,915–99,894,104 | 93 bp | At TSS Multiome | 817 | |
| chr8:100,105,612–100,106,523 | 212.4 kb | Distal (>10kb) Multiome | 186 | |
| chr8:100,145,361–100,146,165 | 252.1 kb | Distal (>10kb) Multiome | 584 | |
| chr8:100,149,973–100,150,933 | 256.9 kb | Distal (>10kb) Multiome | 732 | |
| chr8:100,157,695–100,158,647 | 264.5 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the COX6C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.