TOMM7

translocase of outer mitochondrial membrane 7 | Tom7

This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]

Member of: DE-1 DE-1.10 Developmental clusters: GC4

Biological processes 18 terms

mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrion (GO:0005739)mitochondrion (GO:0005739)positive regulation of protein localization to mitochondrion (GO:1903749)positive regulation of protein localization to mitochondrion (GO:1903749)positive regulation of type 2 mitophagy (GO:1905091)protein binding (GO:0005515)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein insertion into mitochondrial outer membrane (GO:0045040)regulation of protein stability (GO:0031647)transmembrane protein transporter activity (GO:0008320)

Expression (TPM)

TFs regulating TOMM7 0 TFs

Transcription factors with Perturb-seq knockdown data for TOMM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TOMM7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:22,549,622–22,550,567	272.5 kb	Distal (>10kb) Multiome HiCAR	336
chr7:22,703,088–22,703,942	119.3 kb	Distal (>10kb) Multiome	251
chr7:22,708,694–22,710,118	113.4 kb	Distal (>10kb) Multiome	287
chr7:22,782,701–22,783,430	39.7 kb	Distal (>10kb) Multiome	163
chr7:22,821,297–22,821,723	1.1 kb	Proximal (<10kb)	119
chr7:22,822,496–22,823,057	46 bp	At TSS Multiome	671
chr7:22,853,488–22,855,243	31.5 kb	Distal (>10kb) Multiome	941
chr7:22,937,587–22,938,683	115.4 kb	Distal (>10kb) Multiome	139
chr7:23,013,184–23,014,464	191.4 kb	Distal (>10kb) Multiome	751
chr7:23,105,409–23,106,715	283.0 kb	Distal (>10kb) Multiome	833
chr7:23,116,020–23,116,472	293.3 kb	Distal (>10kb) Multiome	105

Genome Browser

Genomic view of the TOMM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.