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DE-1.1

Submodule 61 genes

Cytosolic ribosome and protein biosynthesis

This 61-gene module is enriched for ribosomal proteins and translation machinery, including MIF, RACK1, FTH1, EEF1A1, and TPT1, with strong enrichment for cytosolic ribosome structure, ribosomal subunits, and cytoplasmic translation processes. Knockdown of TAF10, SOX17, and ZC3H3 activates this module. Knockdown of CTBP1, SMAD3, and GATA4 represses this module.

Key terms: cytoplasmic translation protein biosynthetic process translation protein metabolic process Notable genes: MIF RACK1 FTH1 EEF1A1 TPT1 RPSA RPS19 RPS6 Top TFs: TAF10 CTBP1 SOX17 ZC3H3 SMAD3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (61)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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