MIF

MIF

macrophage migration inhibitory factor | GIF, GLIF

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.1 Developmental clusters: GC2

Biological processes 63 terms

carboxylic acid metabolic process (GO:0019752)cell surface (GO:0009986)cell surface receptor signaling pathway (GO:0007166)chemoattractant activity (GO:0042056)cytokine activity (GO:0005125)cytokine activity (GO:0005125)cytokine activity (GO:0005125)cytokine receptor binding (GO:0005126)cytokine receptor binding (GO:0005126)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)dopachrome isomerase activity (GO:0004167)dopachrome isomerase activity (GO:0004167)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)identical protein binding (GO:0042802)negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of cell migration (GO:0030336)negative regulation of cellular senescence (GO:2000773)negative regulation of gene expression (GO:0010629)negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902166)negative regulation of macrophage chemotaxis (GO:0010760)negative regulation of mature B cell apoptotic process (GO:0002906)negative regulation of myeloid cell apoptotic process (GO:0033033)phenylpyruvate tautomerase activity (GO:0050178)phenylpyruvate tautomerase activity (GO:0050178)phenylpyruvate tautomerase activity (GO:0050178)plasma membrane (GO:0005886)positive chemotaxis (GO:0050918)positive regulation of B cell proliferation (GO:0030890)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of arachidonate secretion (GO:0090238)positive regulation of cAMP/PKA signal transduction (GO:0141163)positive regulation of cell population proliferation (GO:0008284)positive regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000343)positive regulation of cytokine production (GO:0001819)positive regulation of fibroblast proliferation (GO:0048146)positive regulation of fibroblast proliferation (GO:0048146)positive regulation of innate immune response (GO:0045089)positive regulation of lipopolysaccharide-mediated signaling pathway (GO:0031666)positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081)positive regulation of phosphorylation (GO:0042327)positive regulation of prostaglandin secretion (GO:0032308)positive regulation of tumor necrosis factor production (GO:0032760)prostaglandin biosynthetic process (GO:0001516)protease binding (GO:0002020)protein binding (GO:0005515)protein homotrimerization (GO:0070207)regulation of cellular response to stress (GO:0080135)regulation of macrophage activation (GO:0043030)secretory granule lumen (GO:0034774)vesicle (GO:0031982)

Expression (TPM)

TFs regulating MIF 0 TFs

Transcription factors with Perturb-seq knockdown data for MIF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MIF

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr22:23,716,825–23,717,722	177.0 kb	Distal (>10kb) Multiome	846
	chr22:23,750,563–23,751,795	143.3 kb	Distal (>10kb) Multiome	687
	chr22:23,767,199–23,768,799	126.2 kb	Distal (>10kb) Multiome	812
	chr22:23,772,486–23,773,491	121.5 kb	Distal (>10kb) Multiome	415
	chr22:23,786,359–23,787,793	107.1 kb	Distal (>10kb) Multiome	723
	chr22:23,789,208–23,789,944	105.0 kb	Distal (>10kb) Multiome	146
	chr22:23,804,750–23,805,326	89.4 kb	Distal (>10kb) Multiome	44
	chr22:23,838,611–23,839,672	55.2 kb	Distal (>10kb) Multiome	472
	chr22:23,849,291–23,849,993	44.7 kb	Distal (>10kb) Multiome	577
	chr22:23,856,822–23,858,514	36.6 kb	Distal (>10kb) Multiome	735
	chr22:23,893,788–23,895,770	1.2 kb	Proximal (<10kb) Multiome	932
	chr22:23,913,645–23,914,284	19.7 kb	Distal (>10kb) Multiome	787
	chr22:23,956,273–23,956,867	62.2 kb	Distal (>10kb) Multiome	182
	chr22:24,010,924–24,011,936	116.9 kb	Distal (>10kb) Multiome	796
	chr22:24,155,850–24,157,427	262.7 kb	Distal (>10kb) Multiome	647

Genome Browser

Genomic view of the MIF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.