This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EEF1A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF1A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF1A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,262,731–73,263,555 | 258.4 kb | Distal (>10kb) Multiome | 460 | |
| chr6:73,314,466–73,315,532 | 206.6 kb | Distal (>10kb) Multiome | 137 | |
| chr6:73,348,234–73,349,695 | 172.1 kb | Distal (>10kb) Multiome | 281 | |
| chr6:73,388,539–73,389,752 | 132.5 kb | Distal (>10kb) Multiome | 579 | |
| chr6:73,450,878–73,452,652 | 69.5 kb | Distal (>10kb) Multiome | 510 | |
| chr6:73,461,207–73,462,355 | 59.8 kb | Distal (>10kb) Multiome | 806 | |
| chr6:73,510,665–73,510,971 | 9.2 kb | Proximal (<10kb) | 39 | |
| chr6:73,511,142–73,516,574 | 7.3 kb | Proximal (<10kb) Multiome | 913 | |
| chr6:73,520,105–73,522,117 | 311 bp | At TSS Multiome | 1220 | |
| chr6:73,523,322–73,523,945 | 3.1 kb | Proximal (<10kb) | 764 | |
| chr6:73,579,484–73,580,917 | 58.9 kb | Distal (>10kb) Multiome HiCAR | 828 | |
| chr6:73,653,023–73,654,818 | 132.4 kb | Distal (>10kb) Multiome HiCAR | 944 | |
| chr6:73,695,662–73,696,526 | 174.6 kb | Distal (>10kb) Multiome | 534 |
Genomic view of the EEF1A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.