Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPS19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:40,810,733–40,811,261 | 1049.3 kb | Distal (>10kb) Multiome HiCAR | 115 | |
| chr19:41,563,228–41,563,884 | 296.7 kb | Distal (>10kb) Multiome | 419 | |
| chr19:41,706,740–41,707,217 | 153.2 kb | Distal (>10kb) Multiome | 420 | |
| chr19:41,850,950–41,851,206 | 9.0 kb | Proximal (<10kb) | 12 | |
| chr19:41,859,455–41,860,753 | 363 bp | At TSS Multiome | 1018 | |
| chr19:41,883,883–41,884,651 | 24.1 kb | Distal (>10kb) Multiome | 917 | |
| chr19:41,887,651–41,888,254 | 27.7 kb | Distal (>10kb) Multiome | 553 | |
| chr19:41,927,700–41,928,620 | 67.9 kb | Distal (>10kb) Multiome | 277 | |
| chr19:41,930,462–41,931,200 | 70.7 kb | Distal (>10kb) Multiome | 147 | |
| chr19:41,957,648–41,959,799 | 98.3 kb | Distal (>10kb) Multiome HiCAR | 839 | |
| chr19:41,993,779–41,994,412 | 134.0 kb | Distal (>10kb) Multiome | 360 | |
| chr19:41,998,577–41,999,349 | 138.6 kb | Distal (>10kb) Multiome | 292 | |
| chr19:42,075,557–42,076,657 | 215.8 kb | Distal (>10kb) Multiome | 846 | |
| chr19:42,095,735–42,096,278 | 235.8 kb | Distal (>10kb) Multiome | 107 | |
| chr19:42,132,949–42,133,545 | 273.0 kb | Distal (>10kb) Multiome | 447 |
Genomic view of the RPS19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.