This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FTH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FTH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FTH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:61,680,168–61,680,631 | 287.3 kb | Distal (>10kb) Multiome | 532 | |
| chr11:61,747,560–61,748,157 | 219.7 kb | Distal (>10kb) Multiome | 493 | |
| chr11:61,752,190–61,753,041 | 215.1 kb | Distal (>10kb) Multiome | 329 | |
| chr11:61,777,258–61,777,759 | 190.2 kb | Distal (>10kb) Multiome | 149 | |
| chr11:61,792,046–61,793,394 | 174.9 kb | Distal (>10kb) Multiome | 896 | |
| chr11:61,814,541–61,817,407 | 152.4 kb | Distal (>10kb) Multiome | 1128 | |
| chr11:61,827,285–61,829,337 | 139.7 kb | Distal (>10kb) Multiome | 728 | |
| chr11:61,871,019–61,871,621 | 96.3 kb | Distal (>10kb) Multiome | 443 | |
| chr11:61,890,974–61,892,214 | 75.9 kb | Distal (>10kb) Multiome HiCAR | 619 | |
| chr11:61,898,986–61,899,424 | 68.3 kb | Distal (>10kb) Multiome | 498 | |
| chr11:61,917,152–61,917,983 | 50.0 kb | Distal (>10kb) Multiome | 465 | |
| chr11:61,955,466–61,956,219 | 11.8 kb | Distal (>10kb) Multiome | 217 | |
| chr11:61,966,654–61,968,718 | 34 bp | At TSS Multiome | 939 | |
| chr11:61,971,541–61,972,360 | 4.4 kb | Proximal (<10kb) Multiome | 877 | |
| chr11:62,123,661–62,124,441 | 156.3 kb | Distal (>10kb) Multiome | 619 |
Genomic view of the FTH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.