This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for TPT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:45,048,778–45,049,467 | 292.0 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr13:45,120,138–45,120,985 | 220.7 kb | Distal (>10kb) Multiome | 723 | |
| chr13:45,249,481–45,250,367 | 91.3 kb | Distal (>10kb) Multiome | 120 | |
| chr13:45,310,992–45,312,067 | 29.8 kb | Distal (>10kb) Multiome | 340 | |
| chr13:45,329,740–45,330,376 | 9.2 kb | Proximal (<10kb) | 320 | |
| chr13:45,331,176–45,331,542 | 8.0 kb | Proximal (<10kb) | 117 | |
| chr13:45,332,996–45,333,477 | 6.1 kb | Proximal (<10kb) | 85 | |
| chr13:45,340,420–45,342,118 | 183 bp | At TSS Multiome | 982 | |
| chr13:45,369,205–45,369,799 | 28.3 kb | Distal (>10kb) Multiome | 26 | |
| chr13:45,370,842–45,371,300 | 29.9 kb | Distal (>10kb) Multiome | 284 | |
| chr13:45,396,133–45,396,998 | 55.5 kb | Distal (>10kb) Multiome | 148 | |
| chr13:45,417,648–45,418,935 | 77.2 kb | Distal (>10kb) Multiome | 793 | |
| chr13:45,464,608–45,465,647 | 123.8 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the TPT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.