The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPRM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:7,221,476–7,222,015 | 345.6 kb | Distal (>10kb) Multiome HiCAR | 177 | |
| chr18:7,256,801–7,257,280 | 310.2 kb | Distal (>10kb) Multiome HiCAR | 20 | |
| chr18:7,277,535–7,278,327 | 289.4 kb | Distal (>10kb) Multiome | 30 | |
| chr18:7,566,497–7,568,918 | 1.3 kb | Proximal (<10kb) Multiome | 625 | |
| chr18:7,573,842–7,574,154 | 6.5 kb | Proximal (<10kb) | 21 | |
| chr18:7,735,065–7,736,214 | 168.4 kb | Distal (>10kb) Multiome | 102 | |
| chr18:7,809,120–7,810,232 | 242.4 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the PTPRM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.