Enables mRNA cap binding complex binding activity. Involved in RNA stabilization. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHAX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHAX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHAX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:126,317,233–126,317,918 | 283.4 kb | Distal (>10kb) Multiome | 47 | |
| chr5:126,368,229–126,369,139 | 232.4 kb | Distal (>10kb) Multiome | 331 | |
| chr5:126,422,966–126,423,868 | 177.6 kb | Distal (>10kb) Multiome | 621 | |
| chr5:126,591,477–126,591,957 | 9.3 kb | Proximal (<10kb) Multiome | 61 | |
| chr5:126,594,453–126,595,707 | 5.7 kb | Proximal (<10kb) Multiome | 803 | |
| chr5:126,599,987–126,601,746 | at TSS | At TSS Multiome | 911 | |
| chr5:126,674,036–126,674,611 | 73.4 kb | Distal (>10kb) Multiome | 99 | |
| chr5:126,718,055–126,718,948 | 117.6 kb | Distal (>10kb) Multiome | 184 | |
| chr5:126,735,879–126,736,525 | 135.4 kb | Distal (>10kb) Multiome | 84 | |
| chr5:126,747,828–126,748,496 | 147.3 kb | Distal (>10kb) Multiome | 495 | |
| chr5:126,776,292–126,778,844 | 176.0 kb | Distal (>10kb) Multiome | 1113 | |
| chr5:126,839,262–126,839,804 | 238.7 kb | Distal (>10kb) Multiome | 90 | |
| chr5:127,289,796–127,291,714 | 689.6 kb | Distal (>10kb) Multiome HiCAR | 438 |
Genomic view of the PHAX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.