This module contains 25 genes including MTDH, CXADR, USP14, E2F4, and BCCIP, with top enriched terms related to nucleotide metabolism, DNA replication, and cell cycle processes. Knockdown of SOX17, NANOG, and OCT4 activates this module. Knockdown of EOMES, GATA4, and FOXA2 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.