This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for LRP8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRP8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRP8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,062,171–53,063,328 | 264.8 kb | Distal (>10kb) Multiome | 134 | |
| chr1:53,115,329–53,116,462 | 211.9 kb | Distal (>10kb) Multiome | 396 | |
| chr1:53,196,600–53,197,254 | 131.2 kb | Distal (>10kb) Multiome | 711 | |
| chr1:53,220,162–53,220,983 | 107.4 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:53,238,114–53,239,137 | 89.4 kb | Distal (>10kb) Multiome | 884 | |
| chr1:53,322,039–53,322,776 | 5.6 kb | Proximal (<10kb) Multiome | 35 | |
| chr1:53,325,739–53,328,473 | 1.6 kb | Proximal (<10kb) Multiome | 856 | |
| chr1:53,328,574–53,329,144 | 600 bp | At TSS | 160 | |
| chr1:53,329,840–53,330,203 | 1.9 kb | Proximal (<10kb) | 17 | |
| chr1:53,384,719–53,385,348 | 57.0 kb | Distal (>10kb) Multiome | 32 | |
| chr1:53,415,199–53,415,709 | 87.5 kb | Distal (>10kb) Multiome | 51 | |
| chr1:53,430,779–53,431,233 | 103.0 kb | Distal (>10kb) Multiome | 103 | |
| chr1:53,434,593–53,435,793 | 107.0 kb | Distal (>10kb) Multiome | 122 | |
| chr1:53,449,173–53,450,171 | 121.9 kb | Distal (>10kb) Multiome | 106 | |
| chr1:53,469,974–53,470,879 | 142.3 kb | Distal (>10kb) Multiome | 301 | |
| chr1:53,485,511–53,485,959 | 157.7 kb | Distal (>10kb) Multiome | 248 |
Genomic view of the LRP8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.